Farmacología

URI permanente para esta comunidadhttps://hdl.handle.net/11441/11024

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Examinando Farmacología por Autor "Alcudia Cruz, Ana"

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    Acceso AbiertoPremio Anual Publicación Científica Destacada de la US. Facultad de Medicina, Premio Mensual Publicación Científica Destacada de la US. Facultad de MedicinaArtículo
    Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn' s Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways
    (MDPI, 2020) Ortiz Cerda, Tamara Andrea; Argüelles Arias, Federico; Illanes Moreno, Matilde; García Montes, Josefa María; Talero Barrientos, Elena Mª; Macías García, Laura; Alcudia Cruz, Ana; Vázquez Román, María Victoria; Motilva Sánchez, Virginia; Miguel Rodríguez, Manuel de; Universidad de Sevilla. Departamento de Farmacología; Universidad de Sevilla. Departamento de Medicina; Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica; Ministerio de Educación y Ciencia (MEC). España; Junta de Andalucía
    Nutraceuticals include a wide variety of bioactive compounds, such as polyphenols, which have been highlighted for their remarkable health benefits. Specially, maqui berries have shown great antioxidant activity and anti-inflammatory effects on some inflammatory diseases. The objectives of the present study were to explore the therapeutic effects of maqui berries on acute-phase inflammation in Crohn’s disease. Balb/c mice were exposed to 2,4,6-trinitrobenzene sulfonic acid (TNBS) via intracolonic administration. Polyphenolic maqui extract (Ach) was administered orally daily for 4 days after TNBS induction (Curative Group), and for 7 days prior to the TNBS induction until sacrifice (Preventive Group). Our results showed that both preventive and curative Ach administration inhibited body weight loss and colon shortening, and attenuated the macroscopic and microscopic damage signs, as well as significantly reducing transmural inflammation and boosting the recovery of the mucosal architecture and its muco-secretory function. Additionally, Ach promotes macrophage polarization to the M2 phenotype and was capable of down-regulating significantly the expression of inflammatory proteins COX-2 and iNOS, and at the same time it regulates the antioxidant Nrf-2/HO-1 pathway. In conclusion, this is the first study in which it is demonstrated that the properties of Ach as could be used as a preventive and curative treatment in Crohn’s disease.