Farmacología

URI permanente para esta comunidadhttps://hdl.handle.net/11441/11024

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Examinando Farmacología por Autor "Abia González, María del Rocío"

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    Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function
    (Royal Society of Chemistry, 2020) Rosillo Ramírez, María de los Ángeles; Montserrat de la Paz, Sergio; Abia González, María del Rocío; Castejón Martínez, María Luisa; Millán-Linares, María del Carmen; Alarcón de la Lastra Romero, Catalina; Fernández-Bolaños Guzmán, José María; Muriana, Francisco J. G.; Universidad de Sevilla. Departamento de Farmacología; Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología; Universidad de Sevilla. Departamento de Química orgánica
    During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) have well established effects on gene networks that stimulate osteoclastogenesis, which is the culprit of several bone diseases. In this study, we investigated the anti-osteoclastogenic effects in vitro of oleuropein (OL) and its peracetylated derivative (Per-OL) by exploring the expression level of key hub genes involved in fate decision and lineage commitment, differentiation, and function of human blood monocyte-derived osteoclasts. Monocytes were purified from peripheral blood mononuclear cells of healthy individuals using commercial antibodies coated with magnetic beads and treated with M-CSF/RANKL in the presence or absence of OL or Per-OL (25 and 50 μM) for 6 days. We demonstrated that OL and especially Per-OL impair transcriptional gene circuits able to support osteoclastogenesis from human blood monocytes. Our results indicate that OL and notably Per-OL are promising candidates to control osteoclastogenesis.