Este archivo ha sido creado el [fecha en formato DD-MM-AAAA] por [Fátima Montiel Herrera y Estrella Díaz Argandoña]
 

GENERAL INFORMATION
------------------

1. Dataset title:
Effects of acute and chronic methylphenidate on prepulse inhibition: A sex difference study in Wistar rats.


2. Authorship:

        Name:Fátima Montiel Herrera
	Institution:Universidad de Sevilla
	Email:fatmonther@outlook.es
	ORCID:0000-0002-7787-3681	

        Name:Adela Batanero Geraldo
	Institution: Universidad de Sevilla
	Email:adelabg@hotmail.com
	ORCID:0009-0003-4561-2836 
        
        Name:Juan Carlos Lopez García
	Institution:Universidad de Sevilla
	Email:jclopez@us.es
	ORCID:0000-0001-8106-5006

        Name:Juan Pedro Vargas Romero
	Institution:Universidad de Sevilla
	Email:vargas@us.es
	ORCID:0000-0002-4358-5737
        
        Name:Esperanza Quintero Sanchez
	Institution:Universidad de Sevilla
	Email:equintero@us.es
	ORCID:0000-0002-6878-9031
        
        Name:Estrella Díaz Argandoña
	Institution:Universidad de Sevilla
	Email:estredi@us.es
	ORCID:0000-0001-9465-9460
       


DESCRIPTION
----------

1. Dataset language:
English


2. Abstract:
In this research, a prepulse inhibition task was carried out in which subjects were treated with a psychostimulant, methylphenidate (MPH), acutely and chronically in a population of Wistar rats.
The dataset contains all the data from a sample of 56 Wistar rats (females and males). These data include the prepulses, pulses and phase of the estrous cycle in which the females were in the different prepulse inhibition sessions.


3. Keywords: 
Methylphenidate, Prepulse Inhibition, Startle reponse, ADHD, Sex Differences, Chronic Administration, Acute Administration,
Estrous cycle.

4. Date of data collection (fecha única o rango de fechas):
01-02-2022 - 21-07-2022

6. Grant information:

	Grant Agency:Ministerio de Ciencia, Innovación y Universidades, FEDER, UE 
	Grant Number : PID2019-110739GB-I00 


7. Geographical location/s of data collection:
Sevilla


ACCESS INFORMATION
------------------------

1. Creative Commons License of the dataset:
CC-BY  

2. Dataset DOI: https://doi.org/10.12795/11441/155734

3. Related publication:


VERSIONING AND PROVENANCE
---------------

2. Were data derived from another source?:
No


METHODOLOGICAL INFORMATION
-----------------------

3. Software or instruments needed to interpret the data:
Statistical Package for the Social Sciences 21 (SPSS)

4. Information about instruments, calibration and standards:
Two startle chambers (Panlab, model LE 111).


5. Environmental or experimental conditions:
Startle stimulus: 120dB
Prepulses:75dB, 85dB, 90dB 
background noise: 65dB


FILE OVERVIEW 
----------------------


1. Explain the file naming conversion, si es aplicable:

Prpulse Inhibition data


2. File list:

	File name:PPI_DATA
	Description: Exel file 


3. Relationship between files:
PPI for Prepulse- Inhibition; Pulse for Block of three trials per session


4. File format:
.xlsx


5. If the dataset includes multiple files, specify the directory structure and relationships between the files:
[ Obligatorio si es aplicable | Si el conjunto de datos incluye varios archivos, indique la estructura de directorios y las relaciones entre los archivos]    
PPI for Prepulse- Inhibition; Pulse for Block of three trials per session


SPECIFIC INFORMATION FOR TABULAR DATA
-------------------------------------------

1. Name file:
PPI_DATA.xlsx


3. Variables list:
(PE for Proestrus-Oestrus;MD for Metaestrus-Diestrous;S for Session;2 for MPH; 0 for Control; M for Male; F for Female; PP75/85/90 for prepulse75/85/90; PPI for Prepulse-inhibition;S1B1... for Session1 Block1...)
SEX
DRUG
CYCLE S1/S2/S3
PULSE1/2/3
PP751/2/3
PP851/2/3
PP901/2/3
PPI751/2/3
PPI851/2/3
PPI901/2/3
PULSE1/2 G7
PP751/2 G7
PP851/2 G7
PP901/2 G7
PPI751/2 G7
PPI851/2 G7
PPI901/2 G7
S1B1
S1B2
S1B3
S1B4
S1B5
S2B1
S2B2
S2B3
S2B4
S2B5
S3B1
S3B2
S3B3
S3B4
S3B5


Variable name:
        Sex: Female (F); Male (M)
Drug: MPH (2); Control (0)
CYCLE:  PROESTRUS-OESTRUS (PE); METAESTRUS-DIESTRUS (MD)


MORE INFORMATION
--------------
S1B1, S1B2... for Block of three trials for sessions (Mean ASR)