Perfil del autor: Robina Ramírez, Inmaculada
Datos institucionales
Nombre | Robina Ramírez, Inmaculada |
Departamento | Química Orgánica |
Área de conocimiento | Química Orgánica |
Categoría profesional | Catedrática de Universidad |
Correo electrónico | Solicitar |
Estadísticas
-
Nº publicaciones
37
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Nº visitas
4434
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Nº descargas
4477
Publicaciones |
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Tesis Doctoral
Synthesis of new nampt inhibitors as potential anti-cancer drugs. An approach to antibody-drug conjugates
(2023)
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the biosynthesis of Nicotinamide Adenine ... |
Artículo
Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
(Elsevier, 2023)
Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ... |
Artículo
Transferring Substituents from Alkynes to Furans and Pyrroles through Heteronorbornadienes as Intermediates: Synthesis of β-Substituted Pyrroles/Furans
(American Chemical Society, 2023)
The use of 7-oxa/azanorbornadienes as synthetic intermediates for the preparation of 3/4-substituted (β-substituted) ... |
Artículo
Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes
(American Chemical Society, 2023)
2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ... |
Artículo
Inter-Ligand STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based ... |
Artículo
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ... |
Artículo
Discovery of human hexosaminidase inhibitors by in situ screening of a library of mono- and divalent pyrrolidine iminosugars
(Elsevier, 2022)
Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized by CuAAC and (thio)urea-bond-forming reactions ... |
Artículo
Iminosugar-Phosphines as Organocatalysts in the [3 + 2] Cycloaddition of Allenoates and N-Tosylimines
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Iminosugar derivatives containing a pyrrolidine-phosphine moiety were prepared from carbohydrates and used as catalysts ... |
Artículo
Studies on the Regioselective Rearrangement of Azanorbornanic Aminyl Radicals into 2,8-Diazabicyclo[3.2.1]oct-2-ene Systems
(American Chemical Society, 2022)
Aminyl radicals are nitrogen-centered radicals of interest in synthetic strategies involving C–N bond formation due to ... |
Tesis Doctoral
Síntesis y reactividad de sistemas [2.2.1]bicíclicos. Estudio de la bioconjugación de proteínas con azanorbornadienos
(2020)
En esta Tesis Doctoral se presentan los resultados más relevantes obtenidos del estudio de reactividad llevado a cabo sobre ... |
Artículo
Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation
(Wiley-Blackwell, 2020)
An azanorbornadiene bromovinyl sulfone reagent for cysteine-selective bioconjugation has been developed. Subsequent reaction ... |
Artículo
Exploring Multi-Subsite Binding Pockets in Proteins: DEEP-STD NMR Fingerprinting and Molecular Dynamics Unveil a Cryptic Subsite at the GM1 Binding Pocket of Cholera Toxin B
(Wiley, 2020)
Ligand-based NMRtechniquesto studyprotein–ligandinteractionsare potenttoolsin drugdesign.Satura-tiontransfer difference ... |
Artículo
Preparation of water-soluble glycopolymers derived from five-membered iminosugars
(Elsevier, 2019)
Iminosugars are carbohydrate mimetics that constitute the main group of oligosaccharide processing enzyme inhibitors. They ... |
Tesis Doctoral |
Artículo
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
(Elsevier, 2019)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives ... |
Artículo
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
(Royal Society of Chemistry, 2019)
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification ... |
Artículo
Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry
(American Chemical Society, 2018)
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in ... |
Tesis Doctoral
Preparación, aplicaciones y reactividad de nuevos derivados de iminoazúcares. Síntesis de análogos del FK866 con propiedades anticáncer
(2017)
En esta Tesis Doctoral se ha desarrollado la síntesis de nuevos (pirrolidín-2-il)-Ctriazoles con configuración L-fuco ... |
Artículo
Mechanistic Insight into the Binding of Multivalent Pyrrolidines to α-Mannosidases
(Wiley-Blackwell, 2017)
Novel pyrrolidine-based multivalent iminosugars, synthesized by a CuAAC approach, have shown remarkable multivalent effects ... |
Artículo
Exploring architectures displaying multimeric presentations of a trihydroxypiperidine iminosugar
(Beilstein-Institut Zur Forderung der Chemischen Wissenschaften, 2015)
The synthesis of new multivalent architectures based on a trihydroxypiperidine α -fucosidase inhibitor is reported herein. ... |
Artículo
Gold nanoparticles are suitable cores for building tunable iminosugar multivalency
(Royal Society of Chemistry: Open Access, 2015)
The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic ... |
Artículo
Synthesis and cancer growth inhibitory activities of 2-fatty-alkylated pyrrolidine-3,4-diol derivatives
(Arkat USA, 2014)
A series of new amphiphilic pyrrolidines containing dodecyl and oleyl apolar side chains were prepared and evaluated for ... |
Artículo
Synthesis and Biological Evaluation of Modified 2-Deoxystreptamine Dimers
(Thieme Publishing; Georg Thieme Verlag, 2011)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for ... |
Artículo
Syntheses and biological activities of 1,4-iminoalditol derivatives as α-L-fucosidase inhibitors
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)
A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of α-l-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented. |
Artículo
Total asymmetric synthesis of monosaccharides and analogues
(Schweizerische Chemische Gesellschaft (Swiss Chemistry Society), 2011)
Since the discovery of the 'formose reaction' by Butlerow,[1] total synthesis of carbohydrates has undergone rapid ... |
Artículo
Monosaccharides and Analogues from Simple Achiral Unsaturated Compounds
(Schweizerische Chemische Gesellschaft, 2011)
We present herein a selection of ingenious methods that have been developed to convert inexpensive furan, pyrrole and unsaturated hydrocarbons into enantiomerically enriched monosaccharides and analogues of biological interest. |
Artículo |
Patente. Invención
Tiofucósidos conteniendo prolinas hidroxiladas, síntesis y usos de los mismos
(Oficina Española de Patentes y Marcas (OEPM), 2010)
Tiofucósidos conteniendo prolinas hidroxiladas, síntesis y usos de los mismos. Compuesto que comprende un tiofucósido ... |
Patente. Invención
Tiofucósidos conteniendo polihidroxialquil-furanos, síntesis y usos de los mismos
(Oficina Española de Patentes y Marcas (OEPM), 2010)
Tiofucósidos conteniendo polihidroxialquil-furanos, síntesis y usos de los mismos. Compuesto que comprende un tiofucósido ... |
Artículo
Synthesis of Novel 3-Amino(Hydroxy)methyl-l-fuco-Azafagomines as Leads for Selective Inhibitors of α-l-Fucosidases
(2010)
The synthesis of 3-substituted l-fuco-azafagomines from d-lyxose is reported. They represent the first example of ... |
Tesis Doctoral
Síntesis estereoselectiva de nuevos furil-aminoácidos y su uso en la preparación de plataformas moleculares y de ligando de biomoléculas
(2009)
Los polihidroxialquil-heterociclos son intermedios sintéticos muy interesantes para la preparación de productos de interés ... |
Artículo
Stereoselective synthesis of chiral furan amino acid analogues of D- and L-serine from D-sugars
(Georg Thieme Verlag, 2006)
The synthesis of chiral furan amino acid analogues of D - and L -serine is reported. The developed methodology starting ... |
Artículo
Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
(Arkat USA, 2002)
Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2, 5-imino-3,4-O-isopropylidene-L-ribose with ... |
Artículo
Synthesis of tri- and tetramines containing two 2,3-dihydroxypyrrolidine moieties and their inhibitory activity toward α-mannosidases
(ARKAT USA INC, 2002)
Through the reductive amination of N-[(tert-butoxy)carbonyl]-2,5-dideoxy-2,5-imino-3,4-Oisopropylidene-L-ribose with ... |
Tesis Doctoral
Sulfoazúcares, sulfoglicolípidos y taurinas N-sustituidas
(2001)
En esta Tesis Doctoral se han preparado C-sulfoazúcares y C-sulfopolioles que contienen un grupo sulfonato (SO3M) en ... |
Tesis Doctoral
Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas
(1999)
La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y ... |
Tesis Doctoral
Aminooligosacaridos. Síntesis de glicosilaminas de disacaridos y de lipooligosacaridos
(1995)
La presente tesis se ha dividido en dos partes: -reacciones regioselectivas en aminoazucares.En esta parte se han preparado ... |