NameLimón Mortés, María Cristina
DepartmentMicrobiología
Knowledge areaMicrobiología
Professional categoryProfesora Contratada Doctora
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Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway

Belmonte Fernández, Alejandro; Herrero Ruiz, Joaquín; Galindo Moreno, María; Limón Mortés, María Cristina; Mora Santos, María del Mar; Sáez, Carmen; Japón, Miguel A.; Tortolero García, María Dolores; Romero Portillo, Francisco (Springer Nature, 2023)
Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment ...
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p53 and FBXW7: Sometimes Two Guardians Are Worse than One

Galindo Moreno, María; Giráldez Macías, Servando; Limón Mortés, María Cristina; Belmonte Fernández, Alejandro; Sáez, Carmen; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (MDPI, 2020)
Too much of a good thing can become a bad thing. An example is FBXW7, a well-known tumor suppressor that may also contribute ...
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Heterologous viral expression systems in fosmid vectors increase the functional analysis potential of metagenomic libraries

Terrón González, L.; Medina Morillas, Carlos; Limón Mortés, María Cristina; Santero Santurino, Eduardo (Nature Publishing Group, 2013)
The extraordinary potential of metagenomic functional analyses to identify activities of interest present in uncultured ...
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Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.

Mora Santos, María del Mar; Limón Mortés, María Cristina; Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (The American Society for Biochemistry and Molecular Biology, 2011)
PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during ...
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UV-induced degradation of securin is mediated by SKP1-CUL1-βTrCP E3 ubiquitin ligase

Limón Mortés, María Cristina; Mora Santos, María del Mar; Espina Zambrano, Águeda Gema; Pintor Toro, José Antonio; López Román, Antonio; Tortolero García, María Dolores; Romero Portillo, Francisco (Company of Biologists, 2008)
Securin is a chaperone protein with bifunctional properties. It binds to separase to inhibit premature sister chromatid ...
PhD Thesis
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Regulación de la estabilidad de la oncoproteína PTTG1/hSecurina

Limón Mortés, María Cristina; Romero Portillo, Francisco; Tortolero García, María Dolores (2007)
El objetico de esta Tesis es el estudio de la relación de la estabilidad de la oncoproteína PTTG1/Sec. Para ello nos ...
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Protein phosphatase 2A stabilizes human securin, whose phosphorylated forms are degraded via the SCF ubiquitin ligase

Gil Bernabé, Ana María; Romero Portillo, Francisco; Limón Mortés, María Cristina; Tortolero García, María Dolores (2006)
Sister chromatid segregation is triggered at the metaphase-to-anaphase transition by the activation of the protease separase. ...