Artículos (Genética)
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Artículo
Histone variant H2A.Z is needed for efficient transcription-coupled NER and genome integrity in UV challenged yeast cells
(Public Library of Science, 2024-09-10)The genome of living cells is constantly challenged by DNA lesions that interfere with cellular processes such as transcription ...
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Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast
(Elsevier, 2023-06)Transcription in Saccharomyces cerevisiae is associated with elevated mutation and this partially reflects enhanced damage ...
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RNA biogenesis and RNA metabolism factors as R-loop suppressors: a hidden role in genome integrity.
(Cold Spring Harbor Laboratory Press, 2024-07)Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more than four decades, transcription ...
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The Beak of Eukaryotic Ribosomes: Life, Work and Miracles
(MDPI, 2024-07-22)Ribosomes are not totally globular machines. Instead, they comprise prominent structural protrusions and a myriad of ...
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PLK1 Regulates CtIP and DNA2 Interplay in Long-range DNA end Resection.
(Cold Spring Harbor Laboratory Press, 2023)DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate ...
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Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales
(Nature Research, 2024-07-18)DNA N6-adenine methylation (6mA) has recently gained importance as an epigenetic modification in eukaryotes. Its function ...
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The RNAi Machinery in the Fungus Fusarium fujikuroi Is Not Very Active in Synthetic Medium and Is Related to Transposable Elements
(Multidisciplinary Digital Publishing Institute (MDPI), 2024-05-16)Small RNAS (sRNAs) participate in regulatory RNA interference (RNAi) mechanisms in a wide range of eukaryotic organisms, ...
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EXO1 and DNA2-mediated ssDNA gap expansion is essential for ATR activation and to maintain viability in BRCA1-deficient cells
(Oxford University Press, 2024-06-24)DNA replication faces challenges from DNA lesions originated from endogenous or exogenous sources of stress, leading to ...
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Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is ...
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BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is ...
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Three Genes Involved in Different Signaling Pathways, carS, wcoA, and acyA, Participate in the Regulation of Fusarin Biosynthesis in Fusarium fujikuroi
(MDPI, 2024)The phytopathogenic fungus Fusarium fujikuroi has a rich secondary metabolism which includes the synthesis of very different ...
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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
(CELL PRESS (Elsevier), 2024)During genome duplication, replication forks (RFs) can be stalled by different obstacles or by depletion of replication ...
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Rat1 promotes premature transcription termination at R-loops
(Oxford University Press, 2024-04-24)Certain DNA sequences can adopt a non-B form in the genome that interfere with DNA-templated processes, including ...
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TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcription
(Nature Research, 2023-11-09)DNA topoisomerase I (TOP1) removes torsional stress by transiently cutting one DNA strand. Such cuts are rejoined by TOP1 ...
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Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of ...
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
(Cell Press, 2023-08-03)To maintain genome integrity, cells must accurately duplicate their genome and repair DNA lesions when they occur. To ...
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Fusarium photoreceptors
(MDPI, 2023-03-04)Light is an important modulating signal in fungi. Fusarium species stand out as research models for their phytopathogenic ...
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Cannabinoids induce cell death in leukaemic cells through Parthanatos and PARP-related metabolic disruptions
(Nature Publishing Group, 2024)BACKGROUND: Several studies have described a potential anti-tumour effect of cannabinoids (CNB). CNB receptor 2 (CB2) is ...
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Transcription-driven DNA supercoiling counteracts H-NS-mediated gene silencing in bacterial chromatin.
(Nature Research, 2024-03-30)In all living cells, genomic DNA is compacted through interactions with dedicated proteins and/or the formation of plectonemic ...
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Analysis of Salmonella lineage-specific traits upon cell sorting
(Frontiers Media SA, 2023-03-29)Microbial cell individuality is receiving increasing interest in the scientific community. Individual cells within clonal ...