dc.creator | Mirón García, María Carmen | es |
dc.creator | Garrido Godino, Ana Isabel | es |
dc.creator | Martínez Fernández, Verónica | es |
dc.creator | Fernández Pevida, Antonio | es |
dc.creator | Cuevas Bermúdez, Abel | es |
dc.creator | Martín Expósito, Manuel | es |
dc.creator | Chávez de Diego, Sebastián | es |
dc.creator | Cruz Díaz, Jesús de la | es |
dc.creator | Navarro, Francisco | es |
dc.date.accessioned | 2016-08-08T11:05:56Z | |
dc.date.available | 2016-08-08T11:05:56Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Mirón García, M.C., Garrido Godino, A.I., Martínez Fernández, V., Fernández Pevida, A., Cuevas Bermúdez, A., Martín Expósito, M.,...,Navarro, F. (2014). The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription. Nucleic acids research, 42 (15), 9666-9676. | |
dc.identifier.issn | 0305-1048 | es |
dc.identifier.uri | http://hdl.handle.net/11441/44287 | |
dc.description.abstract | Bud27, the yeast orthologue of human URI/RMP,
is a member of the prefoldin-like family of ATPindependent molecular chaperones. It has recently
been shown to mediate the assembly of the three
RNA polymerases in an Rpb5-dependent manner. In
this work, we present evidence of Bud27 modulating
RNA pol II transcription elongation. We show that
Bud27 associates with RNA pol II phosphorylated
forms (CTD-Ser5P and CTD-Ser2P), and that its absence affects RNA pol II occupancy of transcribed
genes. We also reveal that Bud27 associatesin vivo
with the Sth1 component of the chromatin remodeling complex RSC and mediates its association with
RNA pol II. Our data suggest that Bud27, in addition
of contributing to Rpb5 folding within the RNA polymerases, also participates in the correct assembly of
other chromatin-associated protein complexes, such
as RSC, thereby modulating their activity | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | Nucleic acids research, 42 (15), 9666-9676. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | 10.1093/nar/gku685 | es |
dc.identifier.doi | 10.1093/nar/gku685 | es |
idus.format.extent | 11 p. | es |
dc.journaltitle | Nucleic acids research | es |
dc.publication.volumen | 42 | es |
dc.publication.issue | 15 | es |
dc.publication.initialPage | 9666 | es |
dc.publication.endPage | 9676 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/44287 | |