dc.creator | Dahiri, Bouchra | es |
dc.creator | Hinojosa, María G. | es |
dc.creator | Carbonero Aguilar, María del Pilar | es |
dc.creator | Cerrillos, Lucas | es |
dc.creator | Ostos, Rosa | es |
dc.creator | Bautista Palomas, Juan Dionisio | es |
dc.creator | Moreno Navarro, Isabel María | es |
dc.date.accessioned | 2024-02-26T11:12:58Z | |
dc.date.available | 2024-02-26T11:12:58Z | |
dc.date.issued | 2023-10 | |
dc.identifier.citation | Dahiri, B., Hinojosa, M.G., Carbonero Aguilar, M.d.P., Cerrillos, L., Ostos, R., Bautista Palomas, J.D. y Moreno Navarro, I.M. (2023). Assessment of the oxidative status in mother-child couples from Seville (Spain): A prospective cohort study. Free Radical Biology and Medicine, 207, 308-319. https://doi.org/10.1016/j.freeradbiomed.2023.08.017. | |
dc.identifier.issn | 0891-5849 | es |
dc.identifier.issn | 1873-4596 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155585 | |
dc.description.abstract | Pregnancy requires a high demand of energy, which leads to an increase of oxidative stress. The aim of this study
was to assess the oxidative status in 200 couples of pregnant women-newborns at the time of delivery, for the
first time, who gave birth in two University Hospitals from the province of Seville. Recruited women filled an
epidemiological questionnaire with their demographic characteristics and dietary habits during pregnancy. At
the time of delivery, both maternal and cord blood samples were collected. Protein oxidation, superoxide dismutase, and catalase levels were measured to assess the oxidative status of these women, together with the levels
of vitamins D, B12, Zn, Se, and Cu. Our results showed a tendency for all biomarkers measured to be higher in
cord blood than in maternal blood. For the correlations established between the OS markers and sociodemographic characteristics, only significant differences for carbonyl groups values were found on both maternal and
cord blood, relating these higher values to the use of insecticides in the women’s homes. For newborns, only a
significant correlation was detected between antioxidant enzymes and the newborn’s weight, specifically for
superoxide dismutase activity. Additionally, the higher values obtained in cord blood might suggest metabolization, while a higher production of ROS and antioxidant enzymes might be required to maintain the balance.
Measured levels for Se were similar in both maternal and cord blood, unlike Cu and Zn, where higher levels were
found for maternal blood than cord blood, indicating a correlation between maternal Se values and SOD as OS
biomarker. Furthermore, vitamin D levels were around the optimum values established, finding a relationship
between vitamin D and new-born’s height, unlike for vitamin B12 values, where a correlation with maternal food
consumption characteristics was established. Overall values were inside normal ranges and consistent for our
population. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación y Agencia Estatal de Investigación de España. MCIN/AEI/10.13039/501100011033 - PID2019-106442RB-C21 | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Free Radical Biology and Medicine, 207, 308-319. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Oxidative stress | es |
dc.subject | Pregnant women | es |
dc.subject | Biomarkers | es |
dc.subject | Cord blood | es |
dc.subject | Maternal blood | es |
dc.title | Assessment of the oxidative status in mother-child couples from Seville (Spain): A prospective cohort study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Nutrición y Bromatología, Toxicología y Medicina Legal | es |
dc.relation.projectID | PID2019-106442RB-C21 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.freeradbiomed.2023.08.017 | es |
dc.identifier.doi | 10.1016/j.freeradbiomed.2023.08.017 | es |
dc.journaltitle | Free Radical Biology and Medicine | es |
dc.publication.volumen | 207 | es |
dc.publication.initialPage | 308 | es |
dc.publication.endPage | 319 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |