Artículo
Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance
Autor/es | Iglesias Blanco, Nieves
Galbis Fuster, Elsa Valencia, Concepción Díaz Blanco, Manuel Jesús Lacroix, Bertrand Paz Báñez, María Violante de |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2020-12 |
Fecha de depósito | 2024-02-01 |
Publicado en |
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Resumen | This study investigates the impact of dual ionic and covalent cross-links (ion-XrL and cov-XrL) on the properties of chitosan-based (CTS) hydrogels as eco-friendly drug delivery systems (DDS) for the model drug diclofenac ... This study investigates the impact of dual ionic and covalent cross-links (ion-XrL and cov-XrL) on the properties of chitosan-based (CTS) hydrogels as eco-friendly drug delivery systems (DDS) for the model drug diclofenac sodium (DCNa). Citric acid and a diiodo-trehalose derivative (ITrh) were the chosen ionic and covalent cross-linker, respectively. The novel hydrogels completely disintegrated within 96 h by means of a hydrolysis process mediated by the enzyme trehalase. As far as the authors are aware, this is the first time that a trehalose derivative has been used as a covalent cross-linker in the formation of biodegradable hydrogels. The impact of CTS concentration and degree of cov-XrL on rheological parameters were examined by means of an experimental model design and marked differences were found between the materials. Hydrogels with maximum elastic properties were achieved at high CTS concentrations and high degrees of cov-XrL. DCNa-loaded formulations displayed well-controlled drug-release profiles strongly dependent on formulation composition (from 17% to 40% in 72 h). Surprisingly, higher degrees of covalent cross-linking led to a boost in drug release. The formulations presented herein provides a simple and straightforward pathway to design fully biodegradable, tailor-made controlled drug delivery systems with improved rheological properties. |
Agencias financiadoras | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía |
Identificador del proyecto | MAT2016-77345-C3-2-P
P12-FPM-1553 |
Cita | Iglesias Blanco, N., Galbis Fuster, E., Valencia, C., Díaz Blanco, M.J., Lacroix, B. y Paz Báñez, M.V.d. (2020). Biodegradable double cross-linked chitosan hydrogels for drug delivery: Impact of chemistry on rheological and pharmacological performance. International Journal of Biological Macromolecules, 165, 2205-2218. https://doi.org/10.1016/j.ijbiomac.2020.10.006. |
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10.1016j.ijbiomac.2020.10.006.pdf | 2.550Mb | [PDF] | Ver/ | Versión aceptada |