dc.creator | Sanz Herrera, José Antonio | es |
dc.creator | Soria Conde, Laureano | es |
dc.creator | Reina Romo, Esther | es |
dc.creator | Torres Hernández, Yadir | es |
dc.creator | Boccaccini, Aldo R. | es |
dc.date.accessioned | 2024-01-15T16:06:28Z | |
dc.date.available | 2024-01-15T16:06:28Z | |
dc.date.issued | 2018-10 | |
dc.identifier.citation | Sanz-Herrera, J.A., Soria Conde, L., Reina-Romo, E., Torres, Y. y Boccaccini, A.R. (2018). Model of dissolution in the framework of tissue engineering and drug delivery. Biomechanics and Modeling in Mechanobiology, 17 (5), 1331-1341. https://doi.org/10.1007/s10237-018-1029-4. | |
dc.identifier.issn | 1617-7959 | es |
dc.identifier.issn | 1617-7940 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153404 | |
dc.description.abstract | Dissolution phenomena are ubiquitously present in biomaterials in many different fields. Despite the advantages of simulation-based design of biomaterials in medical applications, additional efforts are needed to derive reliable models which describe the process of dissolution. A phenomenologically based model, available for simulation of dissolution in biomaterials, is introduced in this paper. The model turns into a set of reaction–diffusion equations implemented in a finite element numerical framework. First, a parametric analysis is conducted in order to explore the role of model parameters on the overall dissolution process. Then, the model is calibrated and validated versus a straightforward but rigorous experimental setup. Results show that the mathematical model macroscopically reproduces the main physicochemical phenomena that take place in the tests, corroborating its usefulness for design of biomaterials in the tissue engineering and drug delivery research areas. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad MAT2015-71284-P | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer | es |
dc.relation.ispartof | Biomechanics and Modeling in Mechanobiology, 17 (5), 1331-1341. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Computational simulation | es |
dc.subject | Dissolution | es |
dc.subject | Drug delivery | es |
dc.subject | Reaction–diffusion equations | es |
dc.subject | Tissue engineering | es |
dc.title | Model of dissolution in the framework of tissue engineering and drug delivery | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Mecánica de Medios Continuos y Teoría de Estructuras | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | MAT2015-71284-P | es |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s10237-018-1029-4 | es |
dc.identifier.doi | 10.1007/s10237-018-1029-4 | es |
dc.contributor.group | Universidad de Sevilla. TEP145: Ingeniería de las Estructuras | es |
dc.journaltitle | Biomechanics and Modeling in Mechanobiology | es |
dc.publication.volumen | 17 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1331 | es |
dc.publication.endPage | 1341 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |