Artículo
Clinical Outcomes after Surgical Resection Combined with Brachytherapy for Uveal Melanomas
Autor/es | Relimpio López, Isabel
Garrido Hermosilla, Antonio Manuel Espejo, Francisco Gessa Sorroche, María Coca, Lourdes Domínguez, Belen Ponte-Zuñiga, Beatriz Terrón, José Antonio |
Departamento | Universidad de Sevilla. Departamento de Cirugía |
Fecha de publicación | 2022 |
Fecha de depósito | 2022-10-25 |
Publicado en |
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Resumen | Currently, brachytherapy is the most commonly used therapeutic approach for uveal melanomas. Surgical resection by means of endoresection or exoresection is an alternative approach. The present report recounts our experience ... Currently, brachytherapy is the most commonly used therapeutic approach for uveal melanomas. Surgical resection by means of endoresection or exoresection is an alternative approach. The present report recounts our experience over 15 years in the treatment of uveal melanoma using a combined approach of resection surgery with brachytherapy. This is a single-center observational retrospective cohort study in which we describe clinical outcomes, complications and survival in 35 cases of melanoma of the iris or the ciliary body after a combination of surgery and brachytherapy or brachytherapy alone. Local treatment of the tumor was successful in all cases with surgery and brachytherapy. The most frequent complications were scleromalacia, bullous keratopathy, retinal toxicity, cataracts, hypotonia, and photophobia. There were three cases of recurrence, all of which were found in the group of patients who had received brachytherapy alone, and in one case we had to perform a secondary enucleation due to tumor growth after brachytherapy. At present, only one patient has died during follow-up due to liver metastases six years after the start of treatment. In carefully selected patients, this approach can be effective and safe, as long as a close follow-up is carried out after surgery. |
Agencias financiadoras | Instituto de Salud Carlos III European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | RD16/0008/0010 |
Cita | Relimpio López, I., Garrido Hermosilla, A.M., Espejo, F., Gessa Sorroche, M., Coca, L., Domínguez, B.,...,Terrón, J.A. (2022). Clinical Outcomes after Surgical Resection Combined with Brachytherapy for Uveal Melanomas. Journal of Clinical Medicine, 11 (66), 1616. https://doi.org/10.3390/jcm11061616. |
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Clinical outcomes.pdf | 9.692Mb | [PDF] | Ver/ | |