dc.creator | Horra Padilla, Carmen de la | es |
dc.creator | Friaza, Vicente | es |
dc.creator | Morilla, Rubén | es |
dc.creator | Delgado, Juan | es |
dc.creator | Medrano, Francisco J. | es |
dc.creator | Miller, Robert F. | es |
dc.creator | Armas, Yaxsier de | es |
dc.creator | Calderón Sandubete, Enrique José | es |
dc.date.accessioned | 2022-09-14T15:02:15Z | |
dc.date.available | 2022-09-14T15:02:15Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Horra Padilla, C.d.l., Friaza, V., Morilla, R., Delgado, J., Medrano, F.J., Miller, R.F.,...,Calderón, E.J. (2021). Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii. Journal of Fungi, 7 (10) | |
dc.identifier.issn | 2309-608X | es |
dc.identifier.uri | https://hdl.handle.net/11441/137063 | |
dc.description.abstract | A Pneumocystis jirovecii is one of the most important microorganisms that cause pneumonia
in immunosupressed individuals. The guideline for treatment and prophylaxis of Pneumocystis
pneumonia (PcP) is the use of a combination of sulfa drug-containing trimethroprim and sulfamethoxazole.
In the absence of a reliable method to culture Pneumocystis, molecular techniques have been
developed to detect mutations in the dihydropteroate synthase gene, the target of sulfa drugs, where
mutations are related to sulfa resistance in other microorganisms. The presence of dihydropteroate
synthase (DHPS) mutations has been described at codon 55 and 57 and found almost around the
world. In the current work, we analyzed the most common methods to identify these mutations, their
geographical distribution around the world, and their clinical implications. In addition, we describe
new emerging DHPS mutations. Other aspects, such as the possibility of transmitting Pneumocystis
mutated organisms between susceptible patients is also described, as well as a brief summary of
approaches to study these mutations in a heterologous expression system. | es |
dc.description.sponsorship | Institute of Health Carlos III, | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Journal of Fungi, 7 (10) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Pneumocystis | es |
dc.subject | Dihydropteroate synthase | es |
dc.subject | Dene mutations | es |
dc.title | Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jirovecii | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Enfermería | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | FIS-PI19/01845 | es |
dc.relation.publisherversion | https://www.mdpi.com/2309-608X/7/10/856/htm | es |
dc.identifier.doi | 10.3390/jof7100856 | es |
dc.journaltitle | Journal of Fungi | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 10 | es |