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Mostrando ítems 1-4 de 4
Artículo
DMAP-Catalysed Sulfinylation of Diacetone-D-Glucose: Improved Method for the Synthesis of Enantiopure tert-Butyl Sulfoxides and tert-Butanesulfinamide
(Wiley Online Library, 2014-11)
An improved method for the tert-butanesulfinylation of diacetone glucose with tert-butanesulfinyl chloride is reported. The method is based on a beneficial effect of catalytic DMAP, which enhances both the rate of the ...
Artículo
Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme
(Elsevier, 2022)
The stereoselective addition of ethyl acetate enolate to the C═N bond of N-tert-butylsulfinylimines has been investigated in depth. A significant effect of the LHMDS amount and the N-sulfinylimine nature on the stereoselectivity ...
Artículo
Sulfinamide Phosphinates as Chiral Catalysts for the Enantioselective Organocatalytic Reduction of Imines
(American Chemical Society, 2016-07)
A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from commercially available starting materials, is reported. The naphthyl derivative SulPhos proved to be ...
Artículo
Síntesis estereoselectiva de una nueva familia de beta -aminoésteres de interés farmacológico como inhibidores potenciales de la agregación plaquetaria.
(Universidad pablo de Olavide, 2015)
Motivación: La utilización de compuestos estereoquímicamente puros presenta numerosas ventajas frente al uso de racematos en la industria farmacéutica, debido principalmente a la estrecha e importante relación existente ...