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Artículo
Passive targeting of high-grade gliomas via the EPR effect: a closed path for metallic nanoparticles?
(Royal Society of Chemistry, 2021-10-28)
Passive tumor targeting via the enhanced permeability and retention (EPR) effect has long been considered the most effective mechanism for the accumulation of nanoparticles inside solid tumors. However, several studies ...
Artículo
Enantioselective synthesis of 4-amino-3,4-dihydrocoumarins and their non-cyclic hydroxyester precursors: Biological evaluation for the treatment of glioblastoma multiforme
(Elsevier, 2022)
The stereoselective addition of ethyl acetate enolate to the C═N bond of N-tert-butylsulfinylimines has been investigated in depth. A significant effect of the LHMDS amount and the N-sulfinylimine nature on the stereoselectivity ...
Artículo
PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents
(American Chemical Society, 2021)
Diagnostic imaging strongly relies on the use of contrast agents (CAs). In general terms, current CAs present undesirable side effects that encourage researchers and pharmaceutical companies to continually search for safer ...
Artículo
Highly water-stable rare ternary Ag-Au-Se nanocomposites as long blood circulation time X-ray computed tomography contrast agents
(Royal Society of Chemistry, 2017)
X-ray computed tomography (CT) is a powerful and widely used medical non-invasive technique that often requires intravenous administration of contrast agents (CAs) to better visualize soft tissues. In this work, we have ...
Artículo
Comprehensive Toxicity Assessment of PEGylated Magnetic Nanoparticles for in vivo applications
(Elsevier, 2019-05-01)
Magnetic nanoparticles (MNPs) represent one of the greatest promises for the development of a new generation of diagnostic agents for magnetic resonance imaging, with improved specificity and safety. Indeed, during the last ...
Artículo
Synthesis and Characterization of Elongated-Shaped Silver Nanoparticles as a Biocompatible Anisotropic SERS Probe for Intracellular Imaging: Theoretical Modeling and Experimental Verification
(MDPI, 2019)
Progress in the field of biocompatible SERS nanoparticles has promising prospects for biomedical applications. In this work, we have developed a biocompatible Raman probe by combining anisotropic silver nanoparticles with ...
Artículo
Deciphering the Parameters to Produce Highly Reproducible and Scalable Iron Oxide Nanoparticles
(Royal Society of Chemistry, 2023)
Nanomedicine has been long hailed as a game changer for treating several ailments, but its translation from bench to bedside is facing some hurdles. Over the past few decades, there have been a plethora of reports regarding ...