Buscar
Mostrando ítems 11-18 de 18
Artículo
Sulfinamide Phosphinates as Chiral Catalysts for the Enantioselective Organocatalytic Reduction of Imines
(American Chemical Society, 2016-07)
A new type of chiral sulfinamide phosphinate catalysts with up to three stereogenic centers, readily accessible from commercially available starting materials, is reported. The naphthyl derivative SulPhos proved to be ...
Artículo
Immunomodulatory Effects of (R)-Sulforaphane on LPS-Activated Murine Immune Cells: Molecular Signaling Pathways and Epigenetic Changes in Histone Markers
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
The aim of this study was to explore the immunomodulatory effects of the natural enantiomer (R)-Sulforaphane (SFN) and the possible signaling pathways involved in an ex vivo model of LPS-stimulated murine peritoneal ...
Artículo
Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification
(Elsevier, 2017)
A library of 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyrans has been synthesized as a new family of non-peptide NK1 receptor ligands by a one-pot cascade process. Their biological effects via interaction with ...
Artículo
An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
(Wiley Online Library, 2018-03)
An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed addition of aryl-boronic acids to trifluoromethyl ketones. This shelf-stable ligand is ...
Artículo
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues
(Royal Society of Chemistry, 2019-11-04)
An improved fully stereoselective synthesis of both enantiomers of rimantadine and its trifluoromethylated analogues has been developed, using N-isopropylsulfinylimines as a starting chiral material, proving the superiority ...
Artículo
Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity
(American Chemical Society, 2021)
NK1R antagonists, investigated for the treatment of several pathologies, have shown encouraging results in the treatment of several cancers. In the present study, we report on the synthesis of carbohydrate-based NK1R ...
Artículo
Síntesis estereoselectiva de una nueva familia de beta -aminoésteres de interés farmacológico como inhibidores potenciales de la agregación plaquetaria.
(Universidad pablo de Olavide, 2015)
Motivación: La utilización de compuestos estereoquímicamente puros presenta numerosas ventajas frente al uso de racematos en la industria farmacéutica, debido principalmente a la estrecha e importante relación existente ...
Artículo
NMR study on the stabilization and chiral discrimination of sulforaphane enantiomers and analogues by cyclodextrins
(Elsevier, 2018)
Sulforaphane (SFN), a phytochemical isolated from broccoli, is an important antitumoral compound with additional beneficial effect on other important diseases. However, the chemical instability of SFN has hampered its clinical ...