Artículos (Medicina): Envíos recientes
Mostrando ítems 1-20 de 956
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Mesenchymal stem cells expanded in vitro with human serum for the treatment of acute and chronic graft-versus-host disease: results of a phase I/II clinical trial
(2011)This trial evaluated the feasibility and efficacy of the infusion of mesenchymal stem cells expanded using human serum ...
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A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction
(Public Library Science, 2021-01-20)Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/ paraganglioma ...
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PTPN13 and beta-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche
(Elsevier, 2015)The regulation of hematopoietic stem cells (HSCs) depends on the integration of the multiple signals received from the ...
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Panobinostat as part of induction and maintenance for elderly patients with newly diagnosed acute myeloid leukemia: phase Ib/II panobidara study
(Ferrata Storti Foundation, 2015)This phase Ib/II trial combined the pan-deacetylase inhibitor panobinostat with chemotherapy followed by panobinostat ...
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Compassionate use of ruxolitinib in acute and chronic graft versus host disease refractory both to corticosteroids and extracorporeal photopheresis
(BioMed Central, 2017)Background: Ruxolitinib is a potent inhibitor of JAK1/2 with proven efcacy in myelofbrosis. In recent years, research in ...
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Vitamin D: Effect on Haematopoiesis and Immune System and Clinical Applications
(MDPI, 2018-09-08)Vitamin D is a steroid-like hormone which acts by binding to vitamin D receptor (VDR). It plays a main role in the calcium ...
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Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation
(Taylor & Francis, 2018)Natural killer (NK) cells are a population of innate type I lymphoid cells essential for early anti-viral responses and ...
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IMiDs mobilize acute myeloid leukemia blasts to peripheral blood through downregulation of CXCR4 but fail to potentiate AraC/Idarubicin activity in preclinical models of non del5q/5q-AML
(Taylor & Francis, 2018)Treatment for acute myeloid leukemia (AML) remains suboptimal and many patients remain refractory or relapse upon standard ...
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Current Status of CAR-T Cell Therapy in Multiple Myeloma
(MDPI, 2021-10-21)Current data on CAR-T cell-based therapy is really promising in multiple myeloma, especially in terms of response. In ...
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Overall clinical and economic impact of non-alcoholic fatty liver disease
(Aran Ediciones S.A., 2021)Objectives: to establish the clinical and economic con sequences (resource utilization and healthcare costs) of non-alcoholic ...
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Fungal microbiota in newborn infants with and without respiratory distress syndrome
(Public Library Science, 2024-04-10)Background Pneumocytis jirovecii infection in preterm newborns has recently been associated with neonatal respiratory ...
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Impact of liver injury on the severity of COVID-19: a systematic review with meta-analysis
(Aran Ediciones S.A., 2021)Background and aims: SARS-CoV-2 is mainly a respiratory virus that has relevant systemic effects. We assessed the impact ...
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Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia
(Elsevier, 2023-01-10)Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect ...
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Ustekinumab in Crohn’s disease: real-world outcomes and predictors of response
(Aran Ediciones S.A., 2022)Background: ustekinumab is a monoclonal antibody that inhibits interleukins IL-12 and IL-23, and is approved for the ...
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Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1- stem cell-like T cells over PD-1+ T cells curbing tumor progression
(Frontiers Media S.A., 2023)Introduction: A high frequency of mutations affecting the gene encoding Herpes Virus Entry Mediator (HVEM, TNFRSF14) is ...
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ECP versus ruxolitinib in steroid-refractory acute GVHD – a retrospective study by the EBMT transplant complications working party
(Frontiers Media S.A., 2023-12-11)Introduction: Extracorporal Photophoresis (ECP) is in clinical use for steroidrefractory and steroid-dependent acute GVHD ...
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Randomized, double-blind, placebo-controlled clinical trial on the usefulness of probiotic Lactobacillus reuteri in bismuth-containing quadruple eradication therapy for infection with Helicobacter pylori
(Aran Ediciones S.A., 2022)Introduction: the primary goal of this study was to com pare gastrointestinal symptom reduction in patients on ...
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Efficacy and safety of tofacitinib in the treatment of ulcerative colitis: real-life experience in Andalusia
(Aran Ediciones S.A., 2022)Background: tofacitinib is a Janus kinase inhibitor approved for the treatment of moderate-severe ulcerative colitis ...
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Diagnostic accuracy of circulating microRNA in hepatitis B virus-related hepatocellular carcinoma: a meta-analysis based on Asian data
(Aran Ediciones S.A., 2022)Background and aim: hepatitis B virus (HBV) is the main risk factor for hepatocellular carcinoma (HCC). We performed a ...
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The HLA-DQA1*05 genotype does not influence the clinical response to ustekinumab and vedolizumab
(Aran Ediciones S.A., 2023)Background: the success of strategies with earlier anti-TNF drugs for the treatment of inflammatory bowel disease (IBD) ...