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Listar Artículos (Instituto de Investigaciones Químicas (IIQ) – CIC Cartuja) por autor "Jiménez Blanco, José Luis"
Mostrando ítems 1-9 de 9
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Artículo
Cell uptake mechanisms of glycosylated cationic pDNA-cyclodextrin nanoparticles
Guilloteau, Nicolas; Bienvenu, Céline; Charrat, Coralie; Jiménez Blanco, José Luis; Díaz Moscoso, Alejandro; Ortiz Mellet, Carmen; García Fernández, José Manuel; Vierling, Pierre; Di Giorgio, Christophe (Royal Society of Chemistry, 2015)The incorporation of carbohydrate functional elements in the architecture of polycationic amphiphilic cyclodextrins (paCDs) ...
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Enhanced Gene Delivery Triggered by Dual pH/Redox Responsive Host-Guest Dimerization of Cyclooligosaccharide Star Polycations
Carbajo Gordillo, Ana Isabel; López Fernández, José; Benito, Juan Manuel; Jiménez Blanco, José Luis; Santana Armas, María Luisa; Marcelo, Gema; Ortiz Mellet, Carmen; García Fernández, José Manuel (Wiley, 2022)A robust strategy is reported to build perfectly monodisperse star polycationscombining a trehalose-based cyclooligosaccharide ...
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Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
Díaz Moscoso, Alejandro; Guilloteau, Nicolas; Bienvenu, Céline; Méndez Ardoy, Alejandro; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Le Gourriérec, Loïc; Di Giorgio, Christophe; Vierling, Pierre; Defaye, Jacques; Ortiz Mellet, Carmen; García Fernández, José Manuel (Elsevier, 2011-10)Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a ...
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Artículo
Molecular Determinants for Cyclo-oligosaccharide-based Nanoparticle-mediated Effective siRNA Transfection
Manzanares, Darío; Araya Durán, Ingrid; Gallego Yerga, Laura; Játiva, Pablo; Márquez Miranda, Valeria; Canan, Jonathan; Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; González Nilo, Fernando Danilo; García Fernández, José Manuel; Ceña, Valentín (Future Medicine Ltd., 2017)Aim: To study the structural requirements that a cyclooligosaccharide-based nanoparticle must fulfill to be an efficient ...
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Artículo
Multivalency in heterogeneous glycoenvironments: Hetero-glycoclusters, -glycopolymers and -glycoassemblies
Jiménez Blanco, José Luis; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry (Great Britain), 2013)Despite efficiently imitating functional ligand presentations in terms of valency and density, most of the reported ...
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Trehalose- and Glucose-Derived Glycoamphiphiles: Small-Molecule and Nanoparticle Toll-Like Receptor 4 (TLR4) Modulators
Rodríguez Lavado, Julio; Sestito, Stefania E.; Cighetti, Roberto; Aguilar Moncayo, Eva M.; Oblak, Alja; Lainšček, Duško; Jiménez Blanco, José Luis; García Fernández, José Manuel; Ortiz Mellet, Carmen; Jerala, Roman; Calabrese, Valentina; Peri, Francesco (American Chemical Society, 2014)An increasing number of pathologies have been linked to Toll-like receptor 4 (TLR4) activation and signaling, therefore ...
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Artículo
Trehalose-based Janus cyclooligosaccharides: the Click synthesis and DNA-directed assembly into pH-sensitive transfectious nanoparticles
Jiménez Blanco, José Luis; Ortega Caballero, Fernando; Blanco Fernández, L.; Carmona, Thais; Marcelo, G.; Martínez Negro, María; Ortiz Mellet, Carmen; García Fernández, José Manuel (Royal Society of Chemistry, 2016)The convergent preparation of Janus molecular nanoparticles by thiourea-‘‘clicking’’ of a,a0 -trehalose halves has been ...
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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties
Carbajo Gordillo, Ana Isabel; Rodríguez Lavado, Julio; Jiménez Blanco, José Luis; Benito Hernández, Juan Manuel; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José Manuel (The Society, 2019-06-19)An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin ...
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Artículo
Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity
Ortega Caballero, Fernando; Santana Armas, Maria L.; Tros de Ilarduya, Conchita; Di Giorgio, Christophe; Tripier, Raphael; Le Bris, Nathalie; Ollier, Cedric; Ortiz Mellet, Carmen; García Fernández, José Manuel; Jiménez Blanco, José Luis; Méndez Ardoy, Alejandro (Royal Society of Chemistry, 2024-03-05)A novel family of precision-engineered gene vectors with well-defined structures built on trehalose and trehalose-based ...