Buscar
Mostrando ítems 1-8 de 8
Artículo
Pharmacological chaperone therapy for Gaucher disease: A patent review
(Taylor & Francis, 2011)
Introduction: Mutations in the gene encoding for acid β-glucosidase (β-glucocerebrosidase, GlcCerase) are seen in Gaucher disease (GD), which give rise to significant protein misfolding effects and result in progressive ...
Artículo
Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery
(Elsevier, 2011-10)
Fully homogeneous facial amphiphiles consisting in a cyclodextrin (CD) platform onto which a polycationic cluster and a multi-tail hydrophobic moiety have been installed (polycationic amphiphilic CDs; paCDs) self-organized ...
Artículo
Different coordination modes of an aryl-substituted hydrotris(pyrazolyl) borate ligand in rhodium and iridium complexes
(Elsevier, 2011)
Complexes TptolRh(C2H4)2 (1a) and TptolRh(CH2C(Me)C(Me)CH2) (1b) have been prepared by reaction of KTptol with the appropriate [RhCl(olefin)2]2 dimer (Tptol means hydrotris(3-p-tolylpyrazol-1-yl)borate). The two complexes ...
Artículo
Alkoxyamine-cyanoborane adducts: Efficient cyanoborane transfer agents
(Royal Society of Chemistry, 2011)
We report the synthesis of the hitherto unknown zwitterionic alkoxyamino cyanoboranes by reduction of O-alkyloximes with sodium cyanoborohydride; unprecedented cyanoboronated N-alkoxyformamidines were also isolated as ...
Artículo
Self-association of a naphthalene-capped-β-cyclodextrin through cooperative strong hydrophobic interactions
(Elsevier, 2011-09-05)
NMR, circular dichroism and fluorescence techniques were used to study the structure in solution of a new β-cyclodextrin derivate in which naphthalene chromophore group is bridged to O(2) and O(3) secondary positions of ...
Artículo
Cyclodextrin-mediated Crystallization of Acid β-glucosidase in Complex with Amphiphilic Bicyclic Nojirimycin Analogues
(Royal Society of Chemistry, 2011)
Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid β-glucosidase (β-glucocerebrosidase, GlcCerase) with amphiphilic bicyclic nojirimycin analogues of the ...
Artículo
Synthesis and reactivity of half-sandwich (η 5 -C 5 Me 5 )Ir(iii) complexes of a cyclometallated aryl phosphine ligand
(Royal Society of Chemistry, 2011)
Reaction of the Ir(iii) dimer [(η 5 -C 5 Me 5 )IrCl 2 ] 2 with PMeXyl 2 (Xyl = 2,6-C 6 H 3 Me 2 ), in the presence of the poorly coordinating base 2,2,6,6-tetramethyl piperidine, gives a chloride complex 1-Cl, resulting ...
Artículo
3-(Piperidin-1-ium-1-yl)-6-azoniaspiro[5.5]undecane dibromide monohydrate
(International Union of Crystallography, 2011)
The title compound, C15H30N2 2+·2Br−·H2O, was synthesized by reaction of 4-piperidinopiperidine with dibromopentane. The dication is built up from three linked piperidine rings, two of which have one quaternary N atom ...