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Mostrando ítems 1-10 de 22
Artículo
Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model
(Nature, 2019-02-11)
An effective specific immunotherapy should contain elements to generate specific recognition (T-cell peptides) and to modulate the immunological response towards a Th1/Treg pattern by enhancing dendritic cells (DCs). We ...
Artículo
Unexpected loss of stereoselectivity in glycosylation reactions during the synthesis of chondroitin sulfate oligosaccharides
(Beilstein-Institut, 2019)
Here, we present an exploratory study on the fluorous-assisted synthesis of chondroitin sulfate (CS) oligosaccharides. Following this approach, a CS tetrasaccharide was prepared. However, in contrast to our previous results, ...
Artículo
Structural insights into the intracellular region of the human magnesium transport mediator CNNM4
(Multidisciplinary Digital Publishing Institute (MDPI), 2019)
The four member family of “Cyclin and Cystathionine β-synthase (CBS) domain divalent metal cation transport mediators”, CNNMs, are the least-studied mammalian magnesium transport mediators. CNNM4 is abundant in the brain ...
Artículo
Phosphane-decorated Platinum Nanoparticles as Efficient Catalysts for H2 Generation from Ammonia Borane and Methanol
(Wiley, 2019)
A series of narrowly dispersed Pt nanoparticles of 1.5-2.2 nm in size stabilized by bulky terphenylphosphane ligands has been synthesized by the organometallic method using [Pt(dba)2] as platinum source. These nanoparticles ...
Artículo
Aluminium(iii) dialkyl 2,6-bisimino-4R-dihydropyridinates(−1): selective synthesis, structure and controlled dimerization
(Royal Society of Chemistry, 2019)
A family of stable and otherwise selectively unachievable 2,6-bisimino-4-R-1,4-dihydropyridinate aluminium (III) dialkyl complexes [AlR’2(4-R-i PrBIPH)] (R = Bn, Allyl; R’ = Me, Et, i Bu) have been synthesized, taking ...
Artículo
Pyridine-Hydrazone Ligands in Asymmetric Palladium-Catalyzed 1,4- and 1,6-Additions of Arylboronic Acids to Cyclic (Di)enones
(Wiley-Blackwell, 2019)
Catalysts generated by combinations of Pd(TFA)2 and enantiomerically pure pyridine-hydrazone ligands have been applied to the 1,4-addition of arylboronic acids to β-substituted cyclic enones, building all-carbon quaternary ...
Artículo
Reactivity of a gold(i)/platinum(0) frustrated Lewis pair with germanium and tin dihalides
(Royal Society of Chemistry, 2019)
The reactivity of germanium and tin dichlorides with a transition metal-only frustrated Lewis pair based on Au(i) and Pt(0) compounds bearing bulky phosphine ligands is described in this work. We have examined both the ...
Artículo
Asymmetric Organocatalytic Synthesis of Fluorinated β-Hydroxy Diazenes
(Wiley-Blackwell, 2019)
The nucleophilic addition of formaldehyde tert-butyl hydrazone to fluoromethyl ketones provides a valuable tool for the synthesis of highly functionalized β-hydroxy β-tri- and difluoromethyl diazenes. Excellent reactivities ...
Artículo
Evaluating stereoelectronic properties of bulky dialkylterphenyl phosphine ligands
(Elsevier, 2019)
The stereoelectronic properties of a series of sterically hindered phosphines containing a terphenyl substituent, PR2Ar’ (R = alkyl; Ar’ = C6H3-2,6-Ar2), have been evaluated by various methods. Their σ-donating capacity ...
Artículo
Editorial: Weak Interactions in Molecular Machinery
(Frontiers Media, 2019)