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Mostrando ítems 11-20 de 34
Artículo
Grafted Sepiolites for the Removal of Pharmaceuticals in Water Treatment
(Springer Nature, 2019)
The increased detection of pharmaceuticals in finished drinking water has become a growing cause of concern in recent years. The removal of atenolol, ranitidine, and carbamazepine by sepiolite, following functionalization ...
Artículo
Ginsenosides act as positive modulators of P2X4 receptors
(American Society for Pharmacology and Experimental Therapeutics (ASPET), 2019)
We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human ...
Artículo
Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7
(Nature Research (part of Springer Nature): Fully open access journals, 2019)
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii. enhancement of P2X7 receptor responses may ...
Artículo
Asymmetric Organocatalytic Synthesis of Fluorinated β-Hydroxy Diazenes
(Wiley-Blackwell, 2019)
The nucleophilic addition of formaldehyde tert-butyl hydrazone to fluoromethyl ketones provides a valuable tool for the synthesis of highly functionalized β-hydroxy β-tri- and difluoromethyl diazenes. Excellent reactivities ...
Artículo
Structural Basis of the Inhibition of GH1 β-glucosidases by Multivalent Pyrrolidine Iminosugars
(Elsevier, 2019)
The synthesis of multivalent pyrrolidine iminosugars via CuAAC click reaction between different pyrrolidine-azide derivatives and tri- or hexavalent alkynyl scaffolds is reported. The new multimeric compounds, together ...
Artículo
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
(MDPI, 2019)
With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance ...
Artículo
Azabicyclic vinyl sulfones for residue-specific dual protein labelling
(Royal Society of Chemistry, 2019)
We have developed [2.2.1]azabicyclic vinyl sulfone reagents that simultaneously enable cysteine-selective protein modification and introduce a handle for further bioorthogonal ligation. The reaction is fast and selective ...
Artículo
Spatially Resolved STD-NMR Applied to the Study of Solute Transport in Biphasic Systems: Application to Protein-Ligand Interactions
(SAGE Publications, 2019)
Fluid biphasic systems are one of the most interesting dynamic systems in chemistry and biochemistry. In nuclear magnetic resonance (NMR) spectroscopy, the study of the solute dynamics across fluid biphasic systems ...
Artículo
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors
(Elsevier, 2019-11-01)
Concerned by the devastating effects of Alzheimer's disease, and the lack of effective drugs, we have carried out the design of a series of tacrine-phenolic heterodimers in order to tackle the multifactorial nature of the ...
Artículo
Arylisoquinoline-derived organoboron dyes with a triaryl skeleton show dual fluorescence
(Beilstein-Institut, 2019)
Se prepararon cuatro nuevos colorantes que derivan de arilisoquinolinas boryiladas, que contienen un tercer residuo de arilo (naftilo, 4-metoxinaftilo, pirenilo o antrilo) que se une a través de un eje estereogénico ...