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Mostrando ítems 31-40 de 58
Artículo
Specificities and Redundancies in the NEL Family of Bacterial E3 Ubiquitin Ligases of Salmonella Enterica Serovar Typhimurium
(Frontiers Media, 2024)
Salmonella enterica serovar Typhimurium expresses two type III secretion systems, T3SS1 and T3SS2, which are encoded in Salmonella pathogenicity island 1 (SPI1) and SPI2, respectively. These are essential virulent factors ...
Artículo
N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
(Springer Nature, 2023)
Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity of cancer cells and their capacity to respond to stress. The higher plasticity of cancer cells highlights ...
Artículo
Genetic Mining of Newly Isolated Salmophages for Phage Therapy
(Multidisciplinary Digital Publishing Institute (MDPI), 2022)
Salmonella enterica, a Gram-negative zoonotic bacterium, is mainly a food-borne pathogen and the main cause of diarrhea in humans worldwide. The main reservoirs are found in poultry farms, but they are also found in wild ...
Artículo
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)
Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a primary immunodeficiency disorder, yet the ...
Artículo
Linker histone H1 prevents R-loop accumulation and genome instability in heterochromatin
(Nature Publishing Group, 2017)
Linker histone H1 is an important structural component of chromatin that stabilizes the nucleosome and compacts the nucleofilament into higher-order structures. The biology of histone H1 remains, however, poorly understood. ...
Artículo
Impact of the White Collar Photoreceptor WcoA on the Fusarium fujikuroi Transcriptome
(Frontiers Media, 2021)
The proteins of the White Collar 1 family (WC) constitute a major class of flavin photoreceptors, widely distributed in fungi, that work in cooperation with a WC 2 protein forming a regulatory complex. The WC complex was ...
Artículo
Defective histone supply causes condensin-dependent chromatin alterations, SAC activation and chromosome decatenation impairment
(Oxford University Press, 2014)
The structural organization of chromosomes is essential for their correct function and dynamics during the cell cycle. The assembly of DNA into chromatin provides the substrate for topoisomerases and condensins, which ...
Artículo
Proteomic insight into the effects of the Salmonella ubiquitin ligase SlrP on host cells
(Elsevier, 2016)
The virulence of the human and animal pathogen Salmonella enterica serovar Typhimurium is dependent on two type III secretion systems. These systems translocate proteins called effectors into eukaryotic host cells. SlrP ...
Artículo
Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function
(Rockefeller University Press, 2011)
The mitotic exit network (MEN) is a signaling cascade that triggers inactivation of the mitotic cyclin-dependent kinases and exit from mitosis. The GTPase Tem1 localizes on the spindle pole bodies (SPBs) and initiates MEN ...
Artículo
Light regulates the degradation of the regulatory protein VE-1 in the fungus Neurospora crassa
(Springer Nature, 2022)
Background: Fungi use light as an environmental signal to regulate developmental transitions that are key aspects of their biological cycles and that are also relevant for their dispersal and infectivity as plant or animal ...