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Mostrando ítems 11-20 de 41
Artículo
Enhanced Gene Regulation by Cooperation between mRNA Decay and Gene Transcription
(Elsevier, 2023)
It has become increasingly clear in the last few years that gene expression in eukaryotes is not a linear process from mRNA synthesis in the nucleus to translation and degradation in the cytoplasm, but works as a circular ...
Artículo
The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability
(Cold Spring Harbor Laboratory Press, 1997)
The yeast HPR1 gene plays an important role in genome stability, as indicated by the observation that hpr1 mutants have high frequencies of DNA repeat recombination and chromosome loss. Here we report that HPR1 is required ...
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Artículo
Subtracting the sequence bias from partially digested MNase-seq data reveals a general contribution of TFIIS to nucleosome positioning
(BioMed Central, 2017)
TFIIS stimulates RNA cleavage by RNA polymerase II and promotes the resolution of backtracking events. TFIIS acts in the chromatin context, but its contribution to the chromatin landscape has not yet been investigated. ...
Artículo
Asymmetric cell division requires specific mechanisms for adjusting global transcription
(Oxford University Press, 2017)
Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division ...
Artículo
Balanced production of ribosome components is required for proper G/S transition in saccharomyces cerevisiae
(American Society for Biochemistry and Molecular Biology Inc., 2013)
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The cellular growth rate controls overall mRNA turnover, and modulates either transcription or degradation rates of particular gene regulons
(Oxford University Press, 2016)
We analyzed 80 different genomic experiments, and found a positive correlation between both RNA polymerase II transcription and mRNA degradation with growth rates in yeast. Thus, in spite of the marked variation in mRNA ...
Artículo
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
(Oxford University Press, 2012)
Transcription factor IIS (TFIIS) stimulates RNA cleavage by RNA polymerase II by allowing backtracked enzymes to resume transcription elongation. Yeast cells do not require TFIIS for viability, unless they suffer severe ...
Artículo
Cytoplasmic 5′-3′ exonuclease Xrn1p is also a genome-wide transcription factor in yeast
(Frontiers Media, 2014)
The 5′ to 3′ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has ...
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