Artículo
Bio-inspired optimization for the molecular docking problem: State of the art, recent results and perspectives
Autor/es | García Godoy, María Jesús
López Camacho, Esteban García Nieto, José Manuel Ser, Javier del Nebro, Antonio J. Aldana Montes, José F. |
Departamento | Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial |
Fecha de publicación | 2019 |
Fecha de depósito | 2021-05-05 |
Publicado en |
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Resumen | Molecular docking is a Bioinformatics method based on predicting the position and orientation of a
small molecule or ligand when it is bound to a target macromolecule. This method can be modeled
as an optimization problem ... Molecular docking is a Bioinformatics method based on predicting the position and orientation of a small molecule or ligand when it is bound to a target macromolecule. This method can be modeled as an optimization problem where one or more objectives can be defined, typically around an energy scoring function. This paper reviews developments in the field of single- and multi-objective metaheuristics for efficiently addressing molecular docking optimization problems. We comprehensively analyze both problem formulations and applied techniques from Evolutionary Computation and Swarm Intelligence, jointly referred to as Bio-inspired Optimization. Our prospective analysis is supported by an experimental study dealing with a molecular docking problem driven by three conflicting objectives, which is tackled by using different multi-objective heuristics. We conclude that genetic algorithms are the most widely used techniques by far, with a noted increasing prevalence of particle swarm optimization in the last years, being these last techniques particularly adequate when dealing with multi-objective formulations of molecular docking problems. We end this experimental survey by outlining future research paths that should be under target in this vibrant area. |
Agencias financiadoras | Ministerio de Economia, Industria y Competitividad (MINECO). España Junta de Andalucía |
Identificador del proyecto | TIN2014- 58304
TIN2017-86049-R P12-TIC-1519 |
Cita | García Godoy, M.J., López Camacho, E., García Nieto, J.M., Ser, J.d., Nebro, A.J. y Aldana Montes, J.F. (2019). Bio-inspired optimization for the molecular docking problem: State of the art, recent results and perspectives. Applied Soft Computing, 79 (June 2019), 30-45. |
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