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Listar por autor "Rodríguez Martínez, José Manuel"
Mostrando ítems 1-20 de 28
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Artículo
Cellular Response to Ciprofloxacin in Low-Level Quinolone-Resistant Escherichia coli
Machuca, Jesús; Recacha, Esther; Briales Martín, Alejandra; Díaz de Alba, Paula; Blázquez, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2017)Bactericidal activity of quinolones has been related to a combination of DNA fragmentation, reactive oxygen species (ROS) ...
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Artículo
Characterization of a clinical isolate of Haemophilus influenzae with a high level of fluoroquinolone resistance
Rodríguez Martínez, José Manuel; López Cerero, Lorena; García Luque, Isabel; Pascual Hernández, Álvaro (Oxford University Press, 2006-01-23)Haemophilus influenzae is one of the bacterial pathogens most likely to be involved in community-acquired respiratory ...
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Clinical characteristics and outcome of bacteraemia caused by Enterobacter cloacae and Klebsiella aerogenes: more similarities than differences
Álvarez-Marín, Rocío; Lepe Jiménez, José Antonio; Gasch-Blasi, Oriol; Rodríguez Martínez, José Manuel; Calvo-Montes, Jorge; Lara-Contreras, Rosario; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Jiménez-Mejías, Manuel E. (Elsevier, 2021)Objectives The genus Enterobacter is a common cause of nosocomial infections. Historically, the most frequent Enterobacter ...
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Artículo
Contribution of hypermutation to fosfomycin heteroresistance in Escherichia coli
Portillo Calderón, Inés María; Ortiz Padilla, Miriam; Rodríguez Martínez, José Manuel; De Gregorio Iaria, Belén; Blázquez, Jesús; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (Oxford University Press, 2020)Objectives: To explore the effect of combining defects in DNA repair systems with the presence of fosfomycin-resistant ...
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Artículo
Detection of low-level fosfomycin-resistant variants by decreasing glucose-6-phosphate concentration in fosfomycin susceptibility determination
Martín Gutiérrez, Guillermo; Docobo Pérez, Fernando; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Blázquez, Jesús; Rodríguez Beltrán, Jerónimo (Multidisciplinary Digital Publishing Institute (MDPI), 2020)Mutations that confer low-level fosfomycin resistance (LLFR) but not clinical resistance in Escherichia coli are increasingly ...
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Artículo
Detection of plasmid-mediated quinolone resistance genes in clinical isolates of Enterobacter spp. in Spain
Calvo, Jorge; Cano, María Elicier; Rodríguez Martínez, José Manuel; Agüero, J.; Pascual Hernández, Álvaro; Velasco Ramírez, María del Carmen; Francia, M. V.; Martínez Martínez, Luis (American Society for Microbiology, 2009)We have studied by PCR and DNA sequencing the presence of the qnrA, qnrB, qnrS, aac(6′)-Ib-cr, qepA, intI1, and ISCR1 genes ...
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Artículo
Disbalancing Envelope Stress Responses as a Strategy for Sensitization of Escherichia coli to Antimicrobial Agents
Recacha Villamor, Esther; Fox, Valeria; Díaz Díaz, Sara; García Duque, Ana; Docobo Pérez, Fernando; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel (Frontiers Media, 2021)Disbalancing envelope stress responses was investigated as a strategy for sensitization of Escherichia coli to antimicrobial ...
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Artículo
Effect of Glycerol on Fosfomycin Activity against Escherichia coli
Ortiz Padilla, Miriam; Portillo Calderón, Inés María; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Fosfomycin is an antimicrobial that inhibits the biosynthesis of peptidoglycan by entering the bacteria through two channels ...
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Artículo
Efficacy of cefepime and imipenem in experimental murine pneumonia caused by porin-deficient Klebsiella pneumoniae producing CMY-2 β-lactamase
Pichardo, Cristina; Rodríguez Martínez, José Manuel; Pachón Ibáñez, María Eugenia; Conejo Gonzalo, Mª Carmen; Martínez Martínez, Luis; Pachón Díaz, Jerónimo; Pascual Hernández, Álvaro (American Society for Microbiology, 2005-08-01)Previous studies have shown decreased in vitro activity of zwitterionic cephalosporins and carbapenems against porin-deficient ...
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Artículo
Evaluation of temocillin efficacy against KPC-2-producing Klebsiella pneumoniae isolates in a hollow-fibre infection model
Rodríguez Ochoa, José Luis; Pérez Palacios, Patricia; Merino Bohórquez, Vicente; Ortiz Padilla, Miriam; Velázquez Escudero, Ana; Rodríguez-Baño, Jesús; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (Oxford University Press, 2024-02-09)Background: Temocillin is an old antimicrobial that is resistant to hydrolysis by ESBLs but has variable activity against ...
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Artículo
Evaluation of three automated systems for susceptibility testing of enterobacteria containing qnrB, qnrS, and/or aac(6′)-Ib-cr
Calvo, Jorge; Cano, María Elicier; Pitart, Cristina; Marco, Francesc; Rodríguez Martínez, José Manuel; Pascual Hernández, Álvaro; Martínez Martínez, Luis (American Society for Microbiology, 2011)The accuracy of the MicroScan WalkAway, BD Phoenix, and Vitek-2 systems for susceptibility testing of quinolones and ...
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Artículo
Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation
Cueto López, Marina de; Rodríguez Martínez, José Manuel; Soriano Pérez, Manuel Jesús; López Cerero, Lorena; Venero Recio, José Luis; Pascual Hernández, Álvaro (American Society for Microbiology, 2008)The fatal outcome of levofloxacin treatment in a patient with bacteremic pneumonia caused by Streptococcus pneumoniae with ...
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Artículo
In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC
Briales, Alejandra; Rodríguez Martínez, José Manuel; González Velasco, Carmen; Díaz de Alba, Paula; Domínguez Herrera, Juan M.; Pachón Díaz, Jerónimo; Pascual Hernández, Álvaro (American Society for Microbiology, 2011-03-01)This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant ...
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Tesis Doctoral
Interacción de mecanismos plasmídicos y cromosómicos de resistencia a Quinolonas en Escherichia coli y su efecto en la resistencia, fitness y toxicidad celular
Machuca Barcena, Jesús (2014-09-18)Las fluoroquinolonas, junto a los beta-lactámicos, son los antimicrobianos de mayor uso clínico. Por tanto la aparición ...
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Artículo
Interplay Among Different Fosfomycin Resistance Mechanisms in Klebsiella Pneumoniae
Ortiz Padilla, M.; Portillo Calderón, I.; De Gregorio Iaria, Belén; Blázquez, J.; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; Docobo Pérez, Fernando (American Society for Microbiology, 2021)The objectives of this study were to characterize the role of the uhpT, glpT, and fosA genes in fosfomycin resistance in ...
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Artículo
Interplay between IncF plasmids and topoisomerase mutations conferring quinolone resistance in the Escherichia coli ST131 clone: stability and resistance evolution
Rodríguez Martínez, José Manuel; López Cerero, Lorena; García-Duque, Ana; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro (Springer, 2021-11-17)The Escherichia coli ST131 H30-Rx subclone vehicles CTX-M-15 plasmids and mutations in gyrA and parC conferring multidrug ...
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Artículo
Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1
Pascual Hernández, Álvaro; Rodríguez Martínez, José Manuel; González Velasco, Carmen; García Luque, Isabel; Cano, María Elicier; Martínez Martínez, Luis (American Society for Microbiology, 2007-06-01)The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant ...
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Tesis Doctoral
Optimisation of the therapeutic potential of fosfomycin against Enterobacteriaceae: characterisation of genetic and physiological factors related to resistance and antimicrobial activity
Ortiz Padilla, Miriam (2023-05-30)Since the discovery of the first antimicrobials, bacteria with resistance mechanisms against them have been detected. The ...
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Artículo
Pharmacodynamics of fosfomycin: Insights into clinical use for antimicrobial resistance
Rodríguez Martínez, José Manuel; Conejo Gonzalo, Mª Carmen; Rodríguez-Baño, Jesús; Pascual Hernández, Álvaro; Docobo Pérez, Fernando (American Society for Microbiology, 2015-09-01)The aim of this study was to improve the understanding of the pharmacokinetic-pharmacodynamic relationships of fosfomycin ...
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Artículo
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants
Sánchez, María B.; Hernández, Álvaro; Rodríguez Martínez, José Manuel; Martínez Martínez, Luis (BioMed Central, 2008)Background Predicting antibiotic resistance before it emerges at clinical settings constitutes a novel approach for ...