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Listar por autor "Joseph, Bertrand"
Mostrando ítems 1-11 de 11
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Artículo
Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
Burguillos García, Miguel Ángel; Hajji, Nabil; Englund, Elisabet; Persson, Annette; Cenci, Maria Angela; Machado, Alberto; Cano, Josefina; Joseph, Bertrand; Venero Recio, José Luis (Elsevier, 2011-01)We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ...
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ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain
Stratoulias, Vassilis; Ruiz Laza, Agustín; Kanatani, Shigeaki; Osman, Ahmed Mohamed; Keane, Lily; Armengol, Jose A.; García Domínguez, Irene; Alonso Bellido, Isabel María; Venero Recio, José Luis; Joseph, Bertrand (Nature Research, 2023)Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized ...
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Caspase signalling controls microglia activation and neurotoxicity
Burguillos García, Miguel Ángel; Deierborg, Tomas; Kavanagh, Edel T.; Persson, Annette; Hajji, Nabil; García Quintanilla, Alberto; Cano, Josefina; Brundin, Patrik; Englund, Elisabet; Venero Recio, José Luis; Joseph, Bertrand (Springer Nature, 2011-04-11)Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis ...
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Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model
Kavanagh, Edel T.; Burguillos García, Miguel Ángel; Carrillo Jiménez, Alejandro; Oliva Martín, María José; Santiago Pavón, Martiniano; Rodhe, Johanna; Joseph, Bertrand; Venero Recio, José Luis (Impact Journals, LLC, 2015)Increasing evidence involves sustained pro-inflammatory microglia activation in the pathogenesis of different neurodegenerative ...
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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Shen, Xianli; Burguillos García, Miguel Ángel; Osman, Ahmed Mohamed; Frijhoff, Jeroen; Carrillo Jiménez, Alejandro; Kanatani, Sachie; Augsten, Martin; Saidi, Dalel; Rodhe, Johanna; Kavanagh, Edel T.; Venero Recio, José Luis; Joseph, Bertrand (Springer Nature, 2016-10-19)Glioma cells recruit and exploit microglia (the resident immune cells of the brain) for their proliferation and invasion ...
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Microglia-secreted galectin-3 acts as a toll-like receptor 4 ligand and contributes to microglial activation
Burguillos García, Miguel Ángel; Svensson, Martina; Schulte, Tim; Boza Serrano, Antonio; García Quintanilla, Alberto; Kavanagh, Edel T.; Santiago Pavón, Martiniano; Viceconte, Nikenza; Oliva Martín, María José; Osman, Ahmed Mohamed; Salomonsson, Emma; Amar, Lahouari; Persson, Annette; Blomgren, Klas; Achour, Adnane; Englund, Elisabet; Leffler, Hakon; Venero Recio, José Luis; Joseph, Bertrand; Deierborg, Tomas (2015)Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory ...
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Microglia: Agents of the CNS Pro-Inflammatory Response
Rodríguez Gómez, José Antonio; Kavanagh, Edel T.; Engskog-Vlachos, Pinelopi; Engskog, Mikael; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Joseph, Bertrand; Hajji, Nabil; Venero Recio, José Luis; Burguillos García, Miguel Ángel (Multidisciplinary Digital Publishing Institute (MDPI), 2020)The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative ...
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Microglial subtypes: diversity within the microglial community
Venero Recio, José Luis; Stratoulias, Vassilis; Tremblay, Marie-Ève; Joseph, Bertrand (EMBO Press, 2019)Microglia are brain-resident macrophages forming the first active immune barrier in the central nervous system. They fulfill ...
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Neuromelanin activates proinflammatory microglia through a caspase-8-dependent mechanism
Viceconte, Nikenza; Burguillos García, Miguel Ángel; Herrera Carmona, Antonio José; Martínez de Pablos, Rocío; Joseph, Bertrand; Venero Recio, José Luis (BioMed Central, 2015)Background We have uncovered a caspase-dependent (caspase-8/caspase-3/7) signaling governing microglia activation and ...
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Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia
Kavanagh, Edel T.; Rodhe, Johanna; Burguillos García, Miguel Ángel; Venero Recio, José Luis; Joseph, Bertrand (Nature Publishing Group, 2014)The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity ...
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Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour
García Domínguez, Irene; Suárez Pereira, Irene; Santiago Pavón, Martiniano; Pérez Villegas, Eva M.; Bravo, Lidia; López Martín, Carolina; Roca Ceballos, María Angustias; García Revilla, Juan; Espinosa Oliva, Ana María; Rodríguez Gómez, José Antonio; Joseph, Bertrand; Berrocoso, Esther; Armengol, José Ángel; Venero Recio, José Luis; Ruiz Laza, Rocío; Martínez de Pablos, Rocío (Elsevier, 2021-01-10)Apoptotic caspases are thought to play critical roles in elimination of excessive and non-functional synapses and removal ...