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Listar por autor "Herrero Ruiz, Joaquín"
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Tesis Doctoral
Búsqueda de nuevos sustratos de SCF-bTrCP implicados en tumorigénesis
Herrero Ruiz, Joaquín (2015-02-10)Esta Tesis se centra en la búsqueda de nuevos sustratos de SCFbTrCP, una ligasa de ubicuitina esencial en la regulación ...
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Artículo
Cisplatin-induced Cell Death Increases the degradation of the MRE11-RAD50-NBS1 Complex Through the Autophagy/lysosomal Pathway
Belmonte Fernández, Alejandro; Herrero Ruiz, Joaquín; Galindo Moreno, María; Limón Mortés, María Cristina; Mora Santos, María del Mar; Sáez, Carmen; Japón, Miguel A.; Tortolero García, María Dolores; Romero Portillo, Francisco (Springer Nature, 2023)Cisplatin and other platinum-based anticancer agents are among the most widely used chemotherapy drugs in the treatment ...
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Artículo
Glycogen Synthase Kinase-3-ß (GSK3ß) negatively regulates PTTG1/human Securin protein stability, and GSK3ß inactivation correlates with securin accumulation in breast tumors.
Mora Santos, María del Mar; Limón Mortés, María Cristina; Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Sáez, Carmen; Japón Rodríguez, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (The American Society for Biochemistry and Molecular Biology, 2011)PTTG1, also known as securin, is an inactivating partner of separase, the major effector for chromosome segregation during ...
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Artículo
SCFFBXW7α modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability
Giráldez Macías, Servando; Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Japón, Miguel Ángel; Tortolero García, María Dolores; Romero Portillo, Francisco (Impact Journals LLC, 2014)The intra-S-checkpoint is essential to control cell progression through S phase under normal conditions and in response ...
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Artículo
βTrCP controls the lysosome-mediated degradation of CDK1, whose accumulation correlates with tumor malignancy
Herrero Ruiz, Joaquín; Mora Santos, María del Mar; Giraldez Macias, Servando; Sáez Torres, Carmen; Romero Portillo, Francisco; Japón Rodríguez, Miguel Ángel (Impact Journals, 2014)n mammals, cell cycle progression is controlled by cyclin-dependent kinases, among which CDK1 plays important roles in the ...