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Listar por autor "Hajji, Nabil"
Mostrando ítems 1-13 de 13
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Artículo
An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogénesis
García-Domínguez, Daniel J.; Hontecillas-Prieto, Lourdes; Andrés León, Eduardo; Sánchez-Molina, Sara; Rodríguez-Núñez, Pablo; Morón, Francisco J.; Hajji, Nabil; Mackintosh, Carlos; Álava Casado, Enrique de (Public Library of Science, 2020)The presence of the chimeric EWSR1-FLI1 oncoprotein is the main and initiating event defining Ewing sarcoma (ES). The ...
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Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
Burguillos García, Miguel Ángel; Hajji, Nabil; Englund, Elisabet; Persson, Annette; Cenci, Maria Angela; Machado, Alberto; Cano, Josefina; Joseph, Bertrand; Venero Recio, José Luis (Elsevier, 2011-01)We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced ...
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Artículo
Arginine deprivation alters microglial polarity and synergizes with radiation to eradicate non-arginine-auxotrophic glioblastoma tumors
Hajji, Nabil; García Revilla, Juan; Sarmiento Soto, Manuel; Perryman, Richard; Symington, Jake J.; Quarles, Chad C.; Orta Vázquez, Manuel Luis; Mateos Cordero, Santiago; Venero Recio, José Luis; Syed, Nelofer (American Society for Clinical Investigation, 2022)New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the ...
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Artículo
Cancer nano-immunotherapy: the novel and promising weapon to fight cancer
García-Domínguez, Daniel J.; López Enriquez, Soledad; Alba Jiménez, Gonzalo; Garnacho Montero, Carmen; Jiménez Cortegana, Carlos; Flores-Campos, Rocío; Cruz Merino, Luis de la; Hajji, Nabil; Sánchez Margalet, Víctor; Hontecillas-Prieto, Lourdes (Mdpi Ag, 2024)Cancer is a complex disease that, despite advances in treatment and the greater understanding of the tumor biology until ...
- Tesis Doctoral
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Artículo
Caspase signalling controls microglia activation and neurotoxicity
Burguillos García, Miguel Ángel; Deierborg, Tomas; Kavanagh, Edel T.; Persson, Annette; Hajji, Nabil; García Quintanilla, Alberto; Cano, Josefina; Brundin, Patrik; Englund, Elisabet; Venero Recio, José Luis; Joseph, Bertrand (Springer Nature, 2011-04-11)Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a decisive role in the pathogenesis ...
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Artículo
Microglia: Agents of the CNS Pro-Inflammatory Response
Rodríguez Gómez, José Antonio; Kavanagh, Edel T.; Engskog-Vlachos, Pinelopi; Engskog, Mikael; Herrera Carmona, Antonio José; Espinosa Oliva, Ana María; Joseph, Bertrand; Hajji, Nabil; Venero Recio, José Luis; Burguillos García, Miguel Ángel (Multidisciplinary Digital Publishing Institute (MDPI), 2020)The pro-inflammatory immune response driven by microglia is a key contributor to the pathogenesis of several neurodegenerative ...
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Artículo
PGC-1alfa controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity
Dabrowska, Aleksandra; Venero Recio, José Luis; Iwasawa, Ryota; Hankir, Mohammed‐khair; Rahman, Sunniyat; Boobis, Alan; Hajji, Nabil (Impact Journals LLC, 2015-04-09)Due to its role in regulation of mitochondrial function, PGC1α is emerging as an important player in ageing and neurodegenerative ...
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Artículo
PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity. (Erratum) Aging, 2015; 7(9): 629‐647.
Dabrowska, Aleksandra; Venero Recio, José Luis; Iwasawa, Ryota; Hankir, Mohammed‐khair; Rahman, Sunniyat; Brigette Henley, Aine; Boobis, Alan; Hajji, Nabil (Impact Journals, 2016)In this article, the additional author Aine Brigette Henley is added to this manuscript: http://www.impactaging.com/papers/v7/n9/pdf/100790.pdf.
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Artículo
Selective histone methyltransferase G9a inhibition reduces metastatic development of Ewing sarcoma through the epigenetic regulation of NEU1
García-Domínguez, Daniel J.; Hajji, Nabil; López Alemany, Roser; Sánchez Molina, Sara; Figuerola Bou, Elisabet; Morón Civanto, Francisco Jesús; Álava Casado, Enrique de; Hontecillas Prieto, Lourdes (Nature Publishing Group, 2022)Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor with high susceptibility to metastasize. The underlying ...
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Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
García-Domínguez, Daniel J.; Hajji, Nabil; Sánchez Molina, Sara; Figuerola Bou, Elisabet; Martínez de Pablos, Rocío; Espinosa Oliva, Ana María; Flores Campos, Rocío; Robles Frías, María José; Álava Casado, Enrique de; Hontecillas Prieto, Lourdes (Springer Nature, 2021)Ewing sarcoma (EWS) is an aggressive bone and soft tissue tumor of children and young adults in which the principal driver ...
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Artículo
Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials
Hontecillas Prieto, Lourdes; Flores Campos, Rocío; Silver, Andrew; Álava Casado, Enrique de; Hajji, Nabil; García-Domínguez, Daniel J. (Frontiers Media S.A., 2020)Chemotherapy is one of the most established and effective treatments for almost all types of cancer. However, the elevated ...
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Artículo
The bitter side of epigenetics: variability and resistance to chemotherapy
Hajji, Nabil; García-Domínguez, Daniel J.; Hontecillas Prieto, Lourdes; O'Neill, Kevin; Álava Casado, Enrique de; Syed, Nelofer (Future Medicine, 2021)One of the major obstacles to the development of effective new cancer treatments and the main factor for the increasing ...