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Listar por autor "Fratta, Simone"
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Artículo
Experimental and Theoretical Analysis of the Thiol-Promoted Fragmentation of 2-Halo-3-tosyl-oxanorbornadienes
Carranza César, Marina; Carmona Asenjo, Ana Teresa; Navo, Claudio D.; Robina Ramírez, Inmaculada; Fratta, Simone; Newburn, Carlos; Jimenez-Oses, Gonzalo; Moreno Vargas, Antonio José (American Chemical Society, 2023)2-Halo-3-tosyl-oxanorbornadienes are able to accept two thiol molecules through an initial nucleophilic substitution, ...
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Artículo
Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors
Franco, Jorge; Piacente, Francesco; Walter, Melanie; Fratta, Simone; Ghanem, Moustafa; Benzi, Andrea; Martínez Bailén, Macarena; Robina Ramírez, Inmaculada; Del Río, Alberto (Multidisciplinary Digital Publishing Institute (MDPI), 2022)NAPRT, the rate-limiting enzyme of the Preiss–Handler NAD biosynthetic pathway, has emerged as a key biomarker for the ...
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Artículo
Synthesis and Structure-activity Relationship of New Nicotinamide Phosphoribosyltransferase Inhibitors with Antitumor Activity on Solid and Haematological Cancer
Fratta, Simone; Biniecka, Paulina; Moreno Vargas, Antonio José; Carmona Asenjo, Ana Teresa; Nahimana, Aimable; Duchosal, Michel A.; Piacente, Francesco; Bruzzone, Santina; Caffa, Irene; Nencioni, Alessio; Robina Ramírez, Inmaculada (Elsevier, 2023)Cancer cells are highly dependent on Nicotinamide phosphoribosyltransferase (NAMPT) activity for proliferation, therefore ...
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Tesis Doctoral
Synthesis of new nampt inhibitors as potential anti-cancer drugs. An approach to antibody-drug conjugates
Fratta, Simone (2023-01-27)Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate-limiting step in the biosynthesis of Nicotinamide Adenine ...